RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis
نویسندگان
چکیده
منابع مشابه
Synovial macrophage-osteoclast differentiation in inflammatory arthritis.
BACKGROUND Pathological bone resorption (marginal erosions and juxta-articular osteoporosis) by osteoclasts commonly occurs in rheumatoid arthritis (RA). OBJECTIVES To define the nature of the mononuclear precursor cells from which osteoclasts are formed in inflamed synovial tissues and to determine the cellular and humoral factors which influence osteoclast differentiation. METHOD Macropha...
متن کاملHuman osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis.
OBJECTIVE To determine whether synovial macrophages and monocytes isolated from patients with rheumatoid arthritis patients are capable of differentiating into osteoclastic bone resorbing cells; and the cellular and humoral conditions required for this to occur. METHODS Macrophages isolated from the synovium and monocytes from the peripheral blood of rheumatoid arthritis patients were culture...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatology
سال: 2016
ISSN: 2326-5191
DOI: 10.1002/art.39837